Transmitter release statistics are meaningful
نویسندگان
چکیده
منابع مشابه
Changes in the statistics of transmitter release during facilitation.
1. The statistical nature of transmitter release during facilitation was studied at single synaptic sites by recording extracellular excitatory junctional potentials from the claw opener muscle in crayfish.2. At low temperatures, single quanta could be counted in the responses to nerve impulses. The distribution of the number of quanta observed (x) was most accurately described by assuming that...
متن کاملCalcium and transmitter release.
The mechanism of transmitter release by intracellular Ca has been explored by recording presynaptic Ca concentration ([Ca2+]i) with Ca-sensitive fluorescent dyes and by controlling [Ca2+]i with photosensitive Ca chelators. [Ca2+]i decays slowly (in seconds) after presynaptic action potentials, while transmitter release lasts only a few ms after each spike at fast synapses. Simulations of Ca dif...
متن کاملQuantitative Aspects of Transmitter Release
The opener-stretcher motor neuron in crayfish makes 50 endings upon each of 1200 muscle fibers. We have calculated the quantal content of junctional potentials produced by individual terminals and by the whole cell at various physiological frequencies. The results show that when the motor neuron is active at 20 impulses/second, it releases 50 quanta/impulse per muscle fiber, or a total of 4.5 x...
متن کاملThe Nanophysiology of Fast Transmitter Release
Action potentials invading the presynaptic terminal trigger discharge of docked synaptic vesicles (SVs) by opening voltage-dependent calcium channels (CaVs) and admitting calcium ions (Ca(2+)), which diffuse to, and activate, SV sensors. At most synapses, SV sensors and CaVs are sufficiently close that release is gated by individual CaV Ca(2+) nanodomains centered on the channel mouth. Other sy...
متن کاملCalcium and transmitter release at nerve terminals.
Dolphin, A. C. and Scott, R. H. (1987) J. Physiol. (London) 386, 1-17 Holz, G. G., Rane, S. G. and Dunlap, K. (1986) Nature (London) 319,670-672 Scott, R. H. and Dolphin, A. C. (1986) Neurosci. Lett. 69,59-64 Lewis, D. L., Weight, F. F. and Luini, A. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 9035-9039 Grassi, F. and Lux, H. D. (1989) Neurosci. Lett. 105, 113-1 19 Dolphin, A. C., Huston, E. and S...
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ژورنال
عنوان ژورنال: Nature
سال: 1978
ISSN: 0028-0836,1476-4687
DOI: 10.1038/271688a0